Facilitated temporal summation of pain at spinal level in Parkinson's disease
Identifieur interne : 000316 ( Main/Exploration ); précédent : 000315; suivant : 000317Facilitated temporal summation of pain at spinal level in Parkinson's disease
Auteurs : Armando Perrotta [Italie] ; Giorgio Sandrini [Italie] ; Mariano Serrao [Italie] ; Simona Buscone [Italie] ; Cristina Tassorelli [Italie] ; Michele Tinazzi [Italie] ; Roberta Zangaglia [Italie] ; Claudio Pacchetti [Italie] ; Michelangelo Bartolo [Italie] ; Francesco Pierelli [Italie] ; Emilia Martignoni [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
English descriptors
Abstract
Background:: Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms. Materials and methods:: We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early‐stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both “on” and “off” treatments with levodopa. Results:: A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected. Conclusions:: The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23458
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Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Università di Verona</wicri:regionArea><wicri:noRegion>Università di Verona</wicri:noRegion></affiliation></author><author><name sortKey="Zangaglia, Roberta" sort="Zangaglia, Roberta" uniqKey="Zangaglia R" first="Roberta" last="Zangaglia">Roberta Zangaglia</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Unit, IRCCS “C. 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Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS “Neuromed”, University of Rome “Sapienza”, Pozzilli, Isernia</wicri:regionArea><wicri:noRegion>Isernia</wicri:noRegion></affiliation></author><author><name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS “Neuromed”, University of Rome “Sapienza”, Pozzilli, Isernia</wicri:regionArea><wicri:noRegion>Isernia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurorehabilitation Unit, University of Rome “Sapienza” Polo Pontino‐ICOT, Latina</wicri:regionArea><wicri:noRegion>Latina</wicri:noRegion></affiliation></author><author><name sortKey="Martignoni, Emilia" sort="Martignoni, Emilia" uniqKey="Martignoni E" first="Emilia" last="Martignoni">Emilia Martignoni</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Medicine, University of Insubria, Varese, Neurorehabilitation Unit and Movement Disorders Unit, IRCCS Fondazione S. Maugeri, Tradate</wicri:regionArea><wicri:noRegion>Tradate</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="442">442</biblScope><biblScope unit="page" to="448">448</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7B0E1E674C04E5BF6B3E68DDF85C0E01CF32FAEB</idno><idno type="DOI">10.1002/mds.23458</idno><idno type="ArticleID">MDS23458</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>nociceptive withdrawal reflex</term><term>pain</term><term>temporal summation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms. Materials and methods:: We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early‐stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both “on” and “off” treatments with levodopa. Results:: A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected. Conclusions:: The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Perrotta, Armando" sort="Perrotta, Armando" uniqKey="Perrotta A" first="Armando" last="Perrotta">Armando Perrotta</name></noRegion><name sortKey="Bartolo, Michelangelo" sort="Bartolo, Michelangelo" uniqKey="Bartolo M" first="Michelangelo" last="Bartolo">Michelangelo Bartolo</name><name sortKey="Bartolo, Michelangelo" sort="Bartolo, Michelangelo" uniqKey="Bartolo M" first="Michelangelo" last="Bartolo">Michelangelo Bartolo</name><name sortKey="Buscone, Simona" sort="Buscone, Simona" uniqKey="Buscone S" first="Simona" last="Buscone">Simona Buscone</name><name sortKey="Martignoni, Emilia" sort="Martignoni, Emilia" uniqKey="Martignoni E" first="Emilia" last="Martignoni">Emilia Martignoni</name><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name><name sortKey="Perrotta, Armando" sort="Perrotta, Armando" uniqKey="Perrotta A" first="Armando" last="Perrotta">Armando Perrotta</name><name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name><name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name><name sortKey="Sandrini, Giorgio" sort="Sandrini, Giorgio" uniqKey="Sandrini G" first="Giorgio" last="Sandrini">Giorgio Sandrini</name><name sortKey="Serrao, Mariano" sort="Serrao, Mariano" uniqKey="Serrao M" first="Mariano" last="Serrao">Mariano Serrao</name><name sortKey="Serrao, Mariano" sort="Serrao, Mariano" uniqKey="Serrao M" first="Mariano" last="Serrao">Mariano Serrao</name><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name><name sortKey="Zangaglia, Roberta" sort="Zangaglia, Roberta" uniqKey="Zangaglia R" first="Roberta" last="Zangaglia">Roberta Zangaglia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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